Pekka Hämäläinen, L’empire comanche, Toulouse, Anacharsis, 2012, 608 p. ;

Pekka Östman

Dmd049239 608..614

The purpose of this study was to quantitatively determine the contribution of PepT1 [peptide transporter 1 (SLC15A1)] to the intestinal permeability of valacyclovir, an ester prodrug of the antiviral drug acyclovir. In situ single-pass intestinal perfusions were employed (pH 6.5 3 90 minutes) to assess the effective permeability (Peff) of 100 mM [ H]valacyclovir in wild-type and PepT1 knockout ...

P. Degond Université de Toulouse (Directeur de thèse)

The trajectories of Kuhlia mugil fish swimming freely in a tank are analyzed in order to develop a model of spontaneous fish movement. The data show that Kuhlia mugil displacement is best described by turning speed and its auto-correlation. The continuous-time process governing this new kind of displacement is modelled by a stochastic differential equation of Ornstein-Uhlenbeck family: the Pers...

P – Kar 2012

As the call for this workshop stated: "Place has become a hot topic in GIScience". But what is place, and what are the implications of developing place-based methods? In my talk, I set out an agenda for place-based methods, and particularly for retrieval based on place. In doing so, I explore how unstructured text and tagged images can, firstly, inform methods which seek to take account of noti...

Npgrj_nsmb_950 608..614

The enzymatic transfer of activated mannose yields mannosides in glycoconjugates and oligoand polysaccharides. Yet, despite its biological necessity, the mechanism by which glycosyltransferases recognize mannose and catalyze its transfer to acceptor molecules is poorly understood. Here, we report broad high-throughput screening and kinetic analyses of both natural and synthetic substrates of Rh...